Dr. Kane’s dedication and success in working with patients with fragile brain architecture has brought her widespread recognition in the field of biometabolic intervention by blending lipid bench science, medical lipid research with clinical medicine by which she coined the term Membrane Medicine. She serves as Director of the NeuroLipid Research Foundation, a 501c3 nonprofit organization in Millville, New Jersey. Her expertise in boldly addressing neurological disorders and lipid disturbance with targeted nutritional intervention for neurological disorders has led to direct biometabolic application utilized by physicians and researchers worldwide. Dr. Kane’s clinical experience, working with physicians, spans 39 years.
Dr. Kane has pioneered targeted metabolic application of the red cell fatty acid analysis from Johns Hopkins Kennedy Krieger Institute’s Peroxisomal Diseases Laboratory over the past 21 years. Using basic blood chemistry / CBC she has been able to integrate biomedical interventions for both pediatric and adult populations with acute as well as chronic conditions. In 2008, she applied a specialized epigenetic analysis ‘a portal into the cell’ whereby images of the membrane surface, phospholipids and mitochondria of each patient along with their DNA adducts were utilized to approach the patient’s epigenetic aberrations. After application of oral and intravenous bioactive lipid intervention, both improvement in the patients’ clinical status and normalization of the phospholipids per red cell analysis and membrane imaging. Dr. Kane’s work has expedited the incorporation of current research and evidence based medicine directly into clinical practice to yield resolution of some of the complex medical disorders of our time.
Having a long standing interest in the challenging area of the treatment of neurological disease, Dr. Kane has approached refractory disorders: Alzheimer’s, Autistic Spectrum Disorders, Pervasive Developmental Delay, Seizure Disorders including refractory status epilepticus, Traumatic Brain Injury, Chronic Traumatic Encephalopathy, Inborn Errors in Metabolism/genetic disorders, Epigenetic insult, Neurotoxicity (Toxic and Viral Encephalopathy, Neurotoxic Fungal exposure), Post Stroke, neuroinflammatory and autoimmune disorders, chronic infections including Neurolyme, psychiatric disorders, Multiple Sclerosis, Motor Neuron and Parkinson’s Disease. Dr. Kane developed an intravenous protocol, the Membrane Stabilizing PK Protocol using IV phospholipid therapy and oral fatty acid supplementation that has resulted in positive patient outcomes being utilized by thousands of physicians in the USA and internationally.
Present research studies include examination of red cell lipid aberrations, ceramides/ lipid rafts, and deformation in the phospholipid membranes in autism, MS, ALS, Parkinson’s and various inherited diseases. Oral and intravenous treatment protocols include targeted lipid therapy with lipid mediators phenylbutyrate, phosphatidylcholine, phosphatidylethanolamine, bioactive lipids and a membrane stabilizing (modified ketogenic) diet directed towards stabilization of cellular, organelle and myelin architecture to normalize organelle function to resolve the accumulation aberrant proteins and lipids characteristic in neurological and orphan diseases.
Dr. Kane has published numerous articles, essays, book chapters and books focusing on evidence based medicine for over 39 years. She contributed two chapters, 1) Seizure Disorders: Balancing Fatty Acids to Stabilize Brain Activity, and 2) Autistic Spectrum Disorder: Dynamic Intervention for Neuronal Membrane Stabilization to the January 2009 medical book, Food and Nutrients in Disease Management, edited by a Johns Hopkins University researcher. She has just completed a medical chapter for Dr. John Bach, MD on neurometabolic oral, enteral and parenteral feeding with bioactive lipids for pediatric and adult populations with neuromuscular disease with Drs. Annette Cartaxo and Thomas Wnorowski. Dr. Kane and colleagues are currently writing a book, Membrane Medicine: A NeuroMetabolic Membrane Stabilizing Approach to Neurological Disease.
Dr. Kane is an accomplished lecturer as well as author, presenting to medical societies and universities annually in the US and abroad. In addition, she teaches a 4-day biomedical course to physicians on Membrane Medicine emphasizing targeted lipid therapy and nutritional biochemistry from a cell membrane stabilizing perspective with neurological application several times annually in the US and abroad. She has presented her work to the NIH, Columbia, Johns Hopkins, University of North Carolina at Chapel Hill, University of Kansas, UMDNJ, Eidgenossische Technische (the MIT of Europe), Lipid Mediators in Health and Disease II Symposium, the Royal Medical Society, EuroFed Lipid Congress, Cardiolipin/Barth Syndrome conference, ISSFAL and NORD (Orphan Disease). Dr. Kane’s innovative work has opened the doors of San Diego Children’s Hospital, Children’s Hospital of Philadelphia, The Cleveland Clinic, Boston Children’s Hospital, Kennedy Krieger Institute, Columbia, UMDNJ, Harvard, Mt. Sinai, and Cornell to neurometabolic lipid pharmacology and Membrane Medicine. Dr. Kane has presented at Grand Rounds at Thomas Jefferson University Hospital Integrative Center and Morristown Atlantic Care Hospital in New Jersey, and to the prestigious Lipid Mediators in Health and Disease organization and the New Jersey Institute for Food, Nutrition & Health.